11 Gennaio 2019 12:30
S3 Seminar Room, Third Floor, Physics Building, FIM Department, Via G. Campi 103, Modena. - S3 Seminar Room, Third Floor, Physics Building, FIM Department, Via G. Campi 103, Modena.
Self-assembly at nano-meter length scale by amphiphilic molecules are relevant not only in several neurodegenerative disorders but also in nano-bio technology. Here, we study protein aggregation using a model system of particles having charge at the core but with solvent repelling surface using Monte-Carlo (MC) simulations and mean field analytical treatment. We observe from our simulations that the hydrophobic particles with mutual harmonic interaction of strength α , exhibit aggregation. Electrostatic repulsion between the particles characterized by Debye screening length κ−1 , controls stability of finite clusters or aggregates, the threshold of aggregation being α ~ κ−1.5 . We support our observations qualitatively from mean field analysis. Speaker: Sutapa Dutta (Department of Chemical Biological & Macro-molecular Sciences, S. N. Bose National Centre for Basic Sciences Block JD, Sector III, Salt Lake, Kolkata-700106, WB, India)